View abstract. View abstract. Hemophila: Do not take dexpanthenol, a derivative of pantothenic acid, if you have hemophila. [Dexpanthenol nasal spray as an effective therapeutic principle for treatment of rhinitis sicca anterior]. Loftus, E. V., Jr., Tremaine, W. J., Nelson, R. A., Shoemaker, J. D., Sandborn, W. J., Phillips, S. F., and Hasan, Y. Dexpanthenol enemas in ulcerative colitis: a pilot study. View abstract. Do not take Vitamin B5 if you are allergic to pantothenic acid or any ingredients contained in this drug. 2002;13(4):173-178. View abstract. Wananukul, S., Limpongsanuruk, W., Singalavanija, S., and Wisuthsarewong, W. Comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of irritant diaper dermatitis from diarrhea: a multicenter study. Hayakawa, R., Matsunaga, K., Ukei, C., and Ohiwa, K. Biochemical and clinical study of calcium pantetheine-S-sulfonate. 1969;9(2):130-135. View abstract. View abstract. 500mg per day often produces satisfactory results. Klin.Oczna 2003;105(3-4):179-181. Stomach blockage: Do not receive injections of dexpanthenol, a derivative of pantothenic acid, if you have a gastrointestinal blockage. Pantothenic acid or vitamin B5 is a promising water-soluble B-complex vitamin that helps in reducing facial acne lesions. Pantothenic acid is important for our bodies to properly use carbohydrates, proteins, and lipids and for healthy skin. PMID: 14808256 [PubMed - indexed for MEDLINE] MeSH Terms. It might increase the risk of bleeding. The recommended amount for adults is 5 mg per day. Mammals and some microbes lack the enzyme for this synthetic step, and so, they are unable to synthesize pantothenic acid and need to obtain it from outside (23, 30). Pantothenic acid supplementation may reduce allergic reactions, especially allergic rhinitis. Keep out of reach of children. Med.Chir Dig. 1. Vitamin B5 is commercially available as D-pantothenic acid, as well as dexpanthenol and calcium pantothenate, which are chemicals made in the lab from D-pantothenic acid. Required fields are marked *. View abstract. Arzneimittelforschung. 2011;146(5):321-325. View abstract. What other names is Pantothenic Acid known by? 1996;209(2-3):84-88. 1971;11(1):10-13. Available at: http://books.nap.edu/books/0309065542/html/. Skin treatment with bepanthen cream versus no cream during radiotherapy-a randomized, controlled trial. \"Pantothenic acid is typically used in combination with other B vitamins in the form of a vitamin B complex formulation,\" said Dr. Sherry Ross, OB/GYN and Women's Health Expert at Providence S… Acide D-Pantothénique, Acide Pantothénique, Ácido Pantoténico, Alcool Pantothénylique, B Complex Vitamin, Calcii Pantothenas, Calcium D-Pantothenate, Calcium Pantothenate, Complexe de Vitamines B, D-Calcium Pantothenate, D-Panthenol, D-Panthénol, D-Pantothénate de Calcium, D-Pantothenic Acid, D-Pantothenyl Alcohol, Dexpanthenol, Dexpanthénol, Dexpanthenolum, Pantéthine, Panthenol, Panthénol, Pantothenate, Pantothénate, Pantothénate de Calcium, Pantothenol, Pantothenylol, Vitamin B5, Vitamin B-5, Vitamina B5, Vitamine B5. Pantothenic acid supplementation may reduce allergic reactions, especially allergic rhinitis.One trial on over 100 patients with allergic rhinitis given 250mg of pantothenic acid twice daily found that the majority had almost instant relief. Klin.Oczna 2003;105(3-4):175-178. Strahlenther.Onkol. Laryngorhinootologie 2003;82(4):266-271. Pantothenic acid is a precursor of coenzyme A which is required for acetylation (acyl group activation) reactions in gluconeogenesis, in the release of energy from carbohydrates, the synthesis and degradation of fatty acids, and the synthesis of sterols and steroid … View abstract. Pantothenic acid has a long list of uses, although there isn't enough scientific evidence to determine whether it is effective for most of these uses. Adamietz, I. Baumeister, M., Buhren, J., Ohrloff, C., and Kohnen, T. Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. Mayo Clin.Proc. Biological Phenomena* Pantothenic Acid* Physiological Phenomena* Vitamin B Deficiency* Substances. This medication contains pantothenic acid. View abstract. It helps prevent early aging and promotes physical growth. It’s necessary for making blood cells, and it helps you convert the food you eat into energy. ‘Pantothenic acid is needed to make coenzyme-A, which is necessary for certain chemical reactions to generate energy from carbohydrates, fats and proteins. Does pantothenic acid accelerate the return of bowel motility in post-operative patients? Kardiologiia. View abstract. It helps alleviate the symptoms of diabetes, skin disorders, osteoarthritis, etc. Zentralbl.Gynakol. Or, you can get pantothenic acid in food rich in the nutrient, including organ meats, fatty fish, shellfish, yeast, egg yolks, avocado, spinach, broccoli, mushrooms, and dairy products. Improved cycling time-trial performance after ingestion of a caffeine energy drink. Abstract. 2007;51(2):239-243. Hautarzt 1993;44(6):380-384. View abstract. View abstract. Povidone-iodine to prevent mucositis in patients during antineoplastic radiochemotherapy. Dosages for supplementation fall between 100mg and 500mg. Acta Oncol 1996;35:1021-6. Brenner A. Cortisone is the primary hormone in preventing the release of histamine and allergic symptoms. 2004;51(2):126-129. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. View abstract. View abstract. J.Altern.Complement Med. The following doses have been studied in scientific research: Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Your email address will not be published. Ivy, J. L., Kammer, L., Ding, Z., Wang, B., Bernard, J. R., Liao, Y. H., and Hwang, J. It also offers smooth and glowing skin. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Livestrong.com also discusses pantothenic acid in relation to allergies, and describes the nutrient's effect on allergies as follows: ‘Pantothenic acid is needed to make coenzyme-A, which is necessary for certain chemical reactions to generate energy from carbohydrates, fats and proteins. The biosynthesis of CoA from pantothenic acid is an essential and View abstract. Int J Sport Nutr Exerc Metab 2009;19(1):61-78. Following are the health benefits of pantothenic acid: 1. Eur.J.Pediatr. A placebo-controlled study. Washington, DC: National Academy Press, 2000. Allergic Rhinitis / Hay Fever. Becker-Schiebe, M., Mengs, U., Schaefer, M., Bulitta, M., and Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis : results of a prospective study in breast cancer patients. View abstract. Raczynska, K., Iwaszkiewicz-Bilikiewicz, B., and Stozkowska, W. [Gel with provitamin B5 applied during tests with the Goldmann triple-mirror]. Eur.Surg.Res. Smolle, M., Keller, C., Pinggera, G., Deibl, M., Rieder, J., and Lirk, P. Clear hydro-gel, compared to ointment, provides improved eye comfort after brief surgery. Minerva Pediatr. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder , autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, breathing problems, celiac disease, colitis, pink eye (conjunctivitis), seizures, and bladder infections. 1972;10(2):103-105. Food and Nutrition Board, Institute of Medicine. Vitamin B5, also known as pantothenic acid, is a water-soluble vitamin that is found in all living cells within the body. Dexpanthenol is given with a needle in to the vein or muscle to improve intestinal movement (intestinal peristalsis), possibly following surgery of the gut, for abdominal bloating (distension) due to reduced intestinal function, and for gas following surgery or pregnancy. Tantilipikorn, P., Tunsuriyawong, P., Jareoncharsri, P., Bedavanija, A., Assanasen, P., Bunnag, C., and Metheetrairut, C. A randomized, prospective, double-blind study of the efficacy of dexpanthenol nasal spray on the postoperative treatment of patients with chronic rhinosinusitis after endoscopic sinus surgery. See Additional Information. A nasal spray containing dexpanthenol is used to reduce the feeling of having a stuffed nose (nasal obstruction) and to reduce a runny nose (nasal discharge). However, some products do not contain all of these ingredients and some may include others, such as biotin, para-aminobenzoic acid (PABA), choline bitartrate, and inositol. 1980;9(1):79-81. It is also applie to reduce skin reactions to radiotherapy treatment, for dry eyes and eye trauma, and for sprains. Vitamin B5 helps strengthen the immune syste… It is heat- and light-stable, but otherwise unstable. Coenzyme-A is also used during the production of cholesterol, hemoglobin, brain chemicals and hormones, especially from the adrenal glands. The metabolism of fats, carbs, and protein all rely to varying degrees on CoA. 2004;180(5):315-322. View abstract. Coenzyme-A is also used during the production of cholesterol, hemoglobin, brain chemicals and hormones, especially from the adrenal glands. Vaxman, F., Olender, S., Lambert, A., Nisand, G., Aprahamian, M., Bruch, J. F., Didier, E., Volkmar, P., and Grenier, J. F. Effect of pantothenic acid and ascorbic acid supplementation on human skin wound healing process. Arnold LE, Christopher J, Huestis RD, Smeltzer DJ. Contact Dermatitis 2003;49(2):80-84. Like other B vitamins, pantothenic acid plays a role in nutrient degradation reactions for energy production. The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial. View abstract. Strahlenther.Onkol. The vitamin is a smart choice during allergy season, when it can be safely taken along with more conventional remedies. A new prophylactic agent in skin care? Haslam RH, Dalby JT, Rademaker AW. Rahn R, Adamietz IA, Boettcher HD, et al. Pantothenic acid, also called vitamin B 5 is a water-soluble B vitamin and therefore an essential nutrient. 2011;187(8):485-491. It is also applied topically for preventing and treating skin reactions to radiation therapy. Dosing considerations for Pantothenic Acid. It is used to treat respiratory disorders and heart problems. It protects the outer layer of the skin against damage caused by environmental toxins. After all, acetyl-CoA is the compound formed from all three energy-producing nutrients, thus holding the central position in energy transformation. Pantothenic acid restores hydration and makes the skin soft and supple. We've talked before about the positive effect of some particular nutrients on preventing and relieving allergy symptoms. People apply dexpanthenol, which is made from pantothenic acid, to the skin for itching, promoting healing of mild eczemas and other skin conditions, insect stings, bites, poison ivy, diaper rash, and acne. Specifically, as DigitalNaturopath.com describes, allergy sufferers who take pantothenic acid supplements before bed often find that their nasal stuffiness clears and they aren't awakened by excess mucus, stuffiness, or other allergy symptoms during the night. Rheumatol.Phys.Med. Camargo, F. B., Jr., Gaspar, L. R., and Maia Campos, P. M. Skin moisturizing effects of panthenol-based formulations. Inhibitory effect of omega-methylpantothenic acid. Shibata, K., Fukuwatari, T., Watanabe, T., and Nishimuta, M. Intra- and inter-individual variations of blood and urinary water-soluble vitamins in Japanese young adults consuming a semi-purified diet for 7 days. Plesofsky-Vig N. Pantothenic acid. Clin.J.Pain 2008;24(8):690-696. Pantothenic acid is also taken by mouth for osteoarthritis, rheumatoid arthritis, Parkinson's disease, premenstrual syndrome (PMS), enlarged prostate, protection against mental and physical stress and anxiety, reducing side effects of thyroid therapy for people with decreased function of the thyroid gland, reducing signs of aging, reducing the risk of getting a cold or other infection, delayed growth, shingles, skin disorders, stimulating adrenal glands, sore mouth (stomatitis), chronic fatigue syndrome, toxicity related to medications such as salicylates or streptomycin, dizziness, constipation, and wound healing. Petri, H., Pierchalla, P., and Tronnier, H. [The efficacy of drug therapy in structural lesions of the hair and in diffuse effluvium--comparative double blind study]. View abstract. Zollner, C., Mousa, S., Klinger, A., Forster, M., and Schafer, M. Topical fentanyl in a randomized, double-blind study in patients with corneal damage. Marquardt, R., Christ, T., and Bonfils, P. [Gelatinous tear substitutes and nonspecific eye ointments in the critical care unit and in perioperative use]. Schreck, U., Paulsen, F., Bamberg, M., and Budach, W. Intraindividual comparison of two different skin care conceptions in patients undergoing radiotherapy of the head-and-neck region. eMedicineHealth does not provide medical advice, diagnosis or treatment. Klykov, N. V. [Use of calcium pantothenate in the treatment of chronic cardiac insufficiency]. Mets, M. A., Ketzer, S., Blom, C., van Gerven, M. H., van Willigenburg, G. M., Olivier, B., and Verster, J. C. Positive effects of Red Bull(R) Energy Drink on driving performance during prolonged driving. Castello, M. and Milani, M. Efficacy of topical hydrating and emollient lotion containing 10% urea ISDIN(R) plus dexpanthenol (Ureadin Rx 10) in the treatment of skin xerosis and pruritus in hemodialyzed patients: an open prospective pilot trial. View abstract. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Kastrup EK. Lokkevik E, Skovlund E, Reitan JB, et al. 1977;6(1):57-59. View abstract. Waterloh, E. and Groth, K. H. [Objectification of the efficacy of an ointment for joint injuries using a volumetric method]. 1995;27(3):158-166. Verse, T., Klocker, N., Riedel, F., Pirsig, W., and Scheithauer, M. O. 1983;33(5):792-795. Anecdotal reports claim that pantothenic acid supplements are effective at 1998;174(3):149-155. In: Shils ME, Olson JA, Shike M, eds. Gobbels, M. and Gross, D. [Clinical study of the effectiveness of a dexpanthenol containing artificial tears solution (Siccaprotect) in treatment of dry eyes]. Acta Anaesthesiol.Scand. Pantothenic acid is safe, even at high doses. Vitamin B5 provides a multitude of benefits to the human body. Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole grain cereals, legumes, eggs, meat, and royal jelly. View abstract. View abstract. St. Louis, MO: Facts and Comparisons, 1998. 2012;95(1):58-63. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. Dexpanthenol, a derivative of pantothenic acid, is POSSIBLY SAFE when applied to the skin, used as a nasal spray, or injected as a shot into the muscle appropriately, short-term. View abstract. 2002;111(3 Pt 1):222-228. J.Med.Assoc.Thai. SHILS ME. Ophthalmologica 2009;223(6):414-418. View abstract. 1966;87(9):785-789. Psychopharmacology (Berl) 2011;214(3):737-745. In high doses, pantothenic acid may inhibit the absorption of biotin produced by microflora in the large intestine; diarrhea may occur. Daeschlein, G., Alborova, J., Patzelt, A., Kramer, A., and Lademann, J. Kinetics of physiological skin flora in a suction blister wound model on healthy subjects after treatment with water-filtered infrared-A radiation. Br.J.Dermatol. Haslock, D. I. and Wright, V. Pantothenic acid in the treatment of osteoarthrosis. Megavitamins for minimal brain dysfunction. View abstract. Vitamin B5 - Pantothenic Acid. Herbst, R. A., Uter, W., Pirker, C., Geier, J., and Frosch, P. J. Allergic and non-allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5-year period. Pantothenic acid is a component of Coenzyme A and also the acyl carrier protein (ACP) of fatty acid synthase (see Chapter 9: Lipids on lipids for many reactions involving CoA). Ann.Otol.Rhinol.Laryngol. 1994;116(7):375-384. View abstract. For instance, omega-3, whether taken as a supplement or through foods, helps a great deal in diminishing eczema symptoms and even allergy symptoms in general. View abstract. 2011;62(4):361-370. 2008;91(10):1558-1563. Allergy sufferers may find pantothenic acid beneficial for controlling the nasal congestion that can develop during an allergic reaction. 2007;69(4):203-206. Webster MJ. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long-term follow-up. 2002;178(6):321-329. S.Afr.J.Surg. Creme or powder? Vitamin B5, also called pantothenic acid, is one of the most important vitamins for human life. It is also taken by mouth for dandruff, depression, diabetic nerve pain, enhancing immune function, improving athletic performance, tongue infections, gray hair, headache, hyperactivity, low blood sugar, trouble sleeping (insomnia), irritability, low blood pressure, multiple sclerosis, muscular dystrophy, leg cramps associated with pregnancy or alcoholism, general nerve pain, and obesity. The majority of these events were mild GI complaints.16 View abstract. View abstract. View abstract. Costa, S. D., Muller, A., Grischke, E. M., Fuchs, A., and Bastert, G. [Postoperative management after cesarean section--infusion therapy and role of intestinal stimulation with parasympathomimetic drugs and dexpanthenon]. Egger, S. F., Huber-Spitzy, V., Alzner, E., Scholda, C., and Vecsei, V. P. Corneal wound healing after superficial foreign body injury: vitamin A and dexpanthenol versus a calf blood extract. A great many enzymes (at least 70) require CoA or ACP rendering pantothenate critical in the metabolism of carbohydrates, fats, and proteins and the functioning of the citric acid cycle. View abstract. Strahlenther.Onkol. People take pantothenic acid for treating dietary deficiencies, acne, alcoholism, allergies, baldness, asthma, attention deficit-hyperactivity disorder (ADHD), autism, burning feet syndrome, yeast infections, heart failure, carpal tunnel syndrome, breathing problems, celiac disease, colitis, pink eye (conjunctivitis), seizures, and bladder infections. [Clinical evaluation of provitamin B5 drops and gel for postoperative treatment of corneal and conjuctival injuries]. HNO 2004;52(7):611-615. 2002;3(6):427-433. Mieny, C. J. Proksch, E. and Nissen, H. P. Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to in general synthesize and metabolize proteins, carbohydrates, and fats.. Pantothenic acid is the combination of pantoic acid and β-alanine. Anon. View abstract. Contact Dermatitis 2004;51(1):13-19. View abstract. Ali, A., Njike, V. Y., Northrup, V., Sabina, A. Patrizi, A., Neri, I., Varotti, E., and Raone, B. [Advance in therapy of acute rhinitis--comparison of efficacy and safety of xylometazoline in combination xylometazoline-dexpanthenol in patients with acute rhinitis]. Pediatrics 1984;74:103-11.. View abstract. Taking Vitamin B5, Pantothenic Acid, for Allergies. 3. D. Nohr, H.K. View abstract. View abstract. Ulcerative colitis: Use enemas containing dexpanthenol, a derivative of pantothenic acid, cautiously if you have ulcerative colitis. Bonnet, Y. and Mercier, R. [Effect of bepanthene in visceral surgery]. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. 2002;146(6):983-991. Thus, the Na + or Ca 2+ salts of panthenol are usually used in pharmaceutical preparations. Pantothenic acid is LIKELY SAFE for most people when taken by mouth in appropriate amounts. J.Med.Assoc.Thai. Pantothenic Acid, Vitamin B5 for Acne ... CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell.
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